Born in Cleveland, Ohio, David B. Keeler studied at Case Western Reserve University
and the Cleveland Institute of Art.

Keeler worked at the Cleveland Museum of Art in the early 1960s followed by a lengthy career at the National Museun of American Art, Smithsonian Instituion as Technical Assistant to the Curator of Exhibitions and Design and later as Chief of Exhibition and Design.

Keeler has exhibited his work in Cleveland, Ohio; Washington D.C.; Alexandria, Virginia; Arlington, Virginia; Tawas, Michigan; West Palm Beach, Florida and Boca Raton, Florida.

Keeler's work is included in a number of collections, both private and public, including the Cleveland Institue of Art, the Hirshorn Museum (Washington D.C.) the Cameron Art Museum (Wilmington, N.C.) and the National Museum of American Art (Washington D.C.)

Reviews and publications have included the Washinton Post, Washington Star, Cleveland Institute of Art Catalogue and Who's Who in American Art.